GSTM1, GSTP1, p53 as some probable predictors of prognosis in primary and metastatic epithelial ovarian cancer

Objectives: Ovarian carcinomas are responsible for the death of more women than all other gynecologic malignancies in Western world. detected an advanced stage disease approximately 80% patients. Glutathione S-transferases (GSTs) important family involved detoxification several xenobiotics. Thus, this mechanism protects tissues from harmful effects oxidative stress and chemical-induced damages. The expression them may contribute to characteristics ovarian carcinoma as they can metabolise both exogenous endogenous compounds, which implicated development cancer. Therefore, our aim was determine expressions GST Mu 1 (GSTM1), Pi (GSTP1), also p53, is a tumor suppressor gene, benign malign tumors metastasis tissues. Methods: A total 99 patients with enrolled study. Thirty-one tumor, 17 51 metastasis. immunohistochemical GSTM1, GSTP1, p53 staining these were investigated. Results: highest noted malignant group followed by group. GSTP1 significantly higher ones (p = 0.015). No statistically significant difference observed level GSTM1 between groups 0.524). < 0.001). Conclusions: indicate that could be biomarkers cancer progression. Further studies cases required confirm results present